《实习医生格蕾第二季》是由彼得·霍顿执导，艾伦·旁派,吴珊卓,Sandra,Oh,贾斯汀·钱伯斯,小詹姆斯·皮肯斯主演的欧美剧。该电视剧于2005年在美国上映。新人们进入第二年实习期，最初的新奇和激情被忙碌、疲劳取代，也慢慢发现被传为“纳粹”的贝利医生严酷外表下是一颗极其善良的心。梅雷迪斯（艾伦·旁派 Ellen Pompeo 饰）与“梦幻先生”德里克（帕特里克·德姆西 Patrick Dempsey 饰）从一夜情正式发展到谈恋爱，怎料“正室”艾迪森（凯特·沃什 kate walsh 饰）出现，原来德里克目前处于和老婆分居状态，一直被他逃避的婚姻问题再度摆上台面，梅雷迪斯倍受煎熬；那边厢，克里斯蒂娜（吴珊卓 Sandra Oh 饰）与黑人医师伯克擦出的火花持续放大，在“怀孕”和“事业”间挣扎，却不幸遭遇流产；伊泽贝尔（凯瑟琳·海格尔 Katherine Heigl 饰）和亚里克斯（贾斯汀·钱伯斯 Justin Chambers 饰）开始约会，发展也并不顺利……
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